Fig. 2
From: Metabolomics identifies plasma biomarkers of localized radiation injury
Broad-spectrum screening. (a) Mutiblock sPLS-DA scatter plots with “macro” block = injury score and skin perfusion and “metabo” block = plasma levels of 19 metabolites. (b) Graphs with the 19 metabolites from the two components with their loading values, representative of the contribution (coefficients in linear combination) of each metabolite for the segregation of one particular group (illustrated with the color). (c) Positive and significant correlation between the component 1 of the DIABLO model and the injury score at day 14 post-irradiation (p-value < 0.0001 and R² = 0.3105). (d) List of each metabolite of the panel (component 1 or 2) with their stability score. (e) Multi-scale correlations (estimated greater than 0.35) between the covariates of each block illustrated by orange (positive) or black (negative) line inside the circle plot. The “macro” block is represented in purple and the “metabo” block in green. Expression of the covariates according to the dose group is shown with colored line outside the circle. Control N = 9, 20 Gy N = 12, 40 Gy N = 11, 80 Gy N = 9.
