Fig. 3
From: Metabolomics identifies plasma biomarkers of localized radiation injury
Suspect screening analysis. (a) Mutiblock sPLS-DA scatter plots with “macro” block = injury score and skin perfusion and “metabo” block = plasma levels of 6 metabolites. (b) Loading plots of the 6 metabolites with their contribution in the component. (c) Positive and significant correlation between the component 1 of the DIABLO model and the injury score at day 14 post-irradiation (p-value < 0.0001 and R² = 0.3393). (d) ROC curves illustrating the performance of the signature to separate each group from the others (AUC) with the associated p-value. (e) Heat-map of the correlations between plasma levels of the metabolites from the signature and injury severity at day 7, 10 and 14 and skin perfusion at day 7 post-irradiation, with positive correlations in red and negative correlations in blue. Control N = 6, 20 Gy N = 11, 40 Gy N = 11, 80 Gy N = 9.
