Table 1 Subject characteristics.

From: Hypothalamic atrophy in primary lateral sclerosis, assessed by convolutional neural network-based automatic segmentation

 

Sex (m/f)

Age

mean ± std

median (range)

Slope*

ALS-FRS-R

Disease duration / years

All PLS (N = 46)

26 / 20

59.8 ± 10.7

59 (35–86)

2.3 ± 1.4

39 ± 7

4.2 ± 4.9

Probable PLS

(N = 28)

17 / 11

59.9 ± 11.2

57 (39–86)

2.9 ± 0.9

42 ± 2

1.6 ± 1.0

Definite PLS

(N = 18)

9 / 9

59.7 ± 10.1

60 (35–74)

1.9 ± 1.6

36 ± 8

7.9 ± 5.9

ALS

(N = 411)

241 / 170

62.4 ± 11.6

64 (21–93)

5.0 ± 5.3

39 ± 8

1.5 ± 1.4

CON (N = 107)

53 / 54

61.4 ± 10.4

64 (38–82)

 

-

-

p-value

-

0.8

 < 0.001#

0.8#

 < 0.001#

  1. ALS-FRS-R – revised ALS functional rating scale25. p-value was calculated by Kruskal–Wallis-test; *slope = (48-ALSFRS-R)/(disease duration); #(ALS vs PLS).
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