Table 2 MR estimates for the association between clonal hematopoiesis and periodontitis.

Exposure	Method	nsnp	b	se	pval	or	or_lci95	or_uci95
Clonal hematopoiesis (overall)	MR Egger	35	1.017	1.348	0.456	2.766	0.197	38.813
	Weighted median	35	0.448	1.064	0.674	1.565	0.194	12.610
	Inverse variance weighted	35	0.481	0.754	0.524	1.617	0.369	7.088
	Simple mode	35	1.812	1.924	0.353	6.124	0.141	265.932
	Weighted mode	35	0.524	1.156	0.653	1.688	0.175	16.270
Clonal hematopoiesis (DNMT3A mutation)	MR Egger	27	−5.866	2.990	0.061	0.003	0.000	0.994
	Weighted median	27	−3.379	1.762	0.055	0.034	0.001	1.078
	Inverse variance weighted	27	−2.475	1.248	0.047	0.084	0.007	0.972
	Simple mode	27	−5.554	3.486	0.123	0.004	0.000	3.592
	Weighted mode	27	−5.675	2.613	0.039	0.003	0.000	0.575
Clonal hematopoiesis (TET2 mutation)	MR Egger	28	1.674	4.875	0.734	5.332	0.000	75263.793
	Weighted median	28	−0.447	3.017	0.882	0.640	0.002	236.719
	Inverse variance weighted	28	−0.559	2.193	0.799	0.572	0.008	42.060
	Simple mode	28	−2.444	5.550	0.663	0.087	0.000	4602.418
	Weighted mode	28	−1.008	3.956	0.801	0.365	0.000	850.292
Clonal hematopoiesis (large clone)	MR Egger	24	3.393	3.360	0.324	29.748	0.041	21544.824
	Weighted median	24	2.028	2.191	0.355	7.599	0.104	557.363
	Inverse variance weighted	24	2.546	1.570	0.105	12.751	0.588	276.649
	Simple mode	24	2.350	3.834	0.546	10.488	0.006	19231.291
	Weighted mode	24	2.242	2.676	0.411	9.408	0.050	1782.738
Clonal hematopoiesis (small clone)	MR Egger	27	3.215	2.098	0.138	24.905	0.408	1520.919
	Weighted median	27	0.666	1.654	0.687	1.947	0.076	49.833
	Inverse variance weighted	27	0.143	1.168	0.903	1.154	0.117	11.386
	Simple mode	27	3.581	2.885	0.226	35.919	0.126	10255.016
	Weighted mode	27	0.960	2.095	0.650	2.613	0.043	158.605

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