Fig. 1 | Scientific Reports

Fig. 1

From: Development of an mPBPK machine learning framework for early target pharmacology assessment of biotherapeutics

Fig. 1

Representation of steps involved in the development of the minimal physiologically based pharmacokinetic / Machine learning modeling framework. mAb: monoclonal antibody, Ag: Antigen or target, MW: Molecular weight, Q: antibody charge, KD: Binding constant, t1/2: target half-life, T0: target baseline, TO: target occupancy, Cmin: minimum plasma concentration, AUCss: area under the curve at steady state, Cmax: maximum plasma concentration, and Css: plasma concentration at steady state.

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