Fig. 5 | Scientific Reports

Fig. 5

From: Development of an mPBPK machine learning framework for early target pharmacology assessment of biotherapeutics

Fig. 5

The effect of different forms of target, soluble (green) or membrane-bound (orange). The decision tree-based boundaries for target properties (half-life and baseline) needed for optimal target occupancy (TO% > 90%) for each target form are shown. The fitted dashed black line (y = 0.324x) separates the optimal properties needed for soluble and membrane-bound receptors that achieve 90% target occupancy.

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