Fig. 6
The ML-derived rules for optimal properties for different sites of action (plasma, leaky tissues, tight tissues). The distribution of drug properties (binding constant, \({\text{K}}_{\text{D}}\) (nM)) and target properties (half-life, \({\text{t}}_{1/2}(\text{hr})\), baseline, \({\text{T}}_{0}\) (nM)) is provided as a pairwise kernel density plot (A, B). The ML-derived rules are quantified as optimal cut-off values for binding constant and target baseline for each site of action (C).
