Fig. 1 | Scientific Reports

Fig. 1

From: Metabolic alterations driven by LDHA in CD8 + T cells promote immune evasion and therapy resistance in NSCLC

Fig. 1

Overview of CD8 T Cell Subsets in NSCLC. (A). UMAP plot showing clustering of CD8 T cell subsets based on scRNA-seq data. Colors represent distinct subsets identified through marker gene expression. (B). The number and proportion of CD8 T cells. (C). Expression profiles of differentially expressed cytokines, MHC, effector molecules, checkpoint receptors, and receptor. (D). Enriched pathways of each T cell subset. (E). Cell communication analysis of LTB + CD8Tn in primary tumors. (The width of the lines represents the strength of the interactions, while the size of the circles reflects the number of cells in each subset), F. Cell communication analysis of LTB + CD8Tn in metastatic tumors. (The width of the lines represents the strength of the interactions, while the size of the circles reflects the number of cells in each subset).

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