Fig. 8 | Scientific Reports

Fig. 8

From: Metabolic alterations driven by LDHA in CD8 + T cells promote immune evasion and therapy resistance in NSCLC

Fig. 8

Poor Prognosis in NSCLC Associated with High LDHA and Low IL7R or GNLY Expression. (A,B). Molecular subtype for LDHA and IL7R in TCGA. (a) Z-score scatter plot of samples, where each point represents a sample and different colors indicate different subgroups. The x and y axes represent the Z-scores of two genes, with Z-score ≤ 0 indicating low expression and Z-score > 0 indicating high expression. (b) Kaplan-Meier survival analysis, with the x-axis representing survival time (t) and the y-axis showing the probability of survival beyond time t. The Log-rank test assesses differences between survival curves, with a p-value < 0.05 considered significant. Pairwise Log-rank test results are presented in a table with a gray background, and the overall Log-rank test result is shown in the bottom left corner. (C,D). Molecular subtype for LDHA and GNLY in TCGA. (E,F). Molecular subtype for LDHA and IL7R in GSE72094. (G,H). Molecular subtype for LDHA and GNLY in GSE72094.

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