Fig. 5

Comparison of the results obtained with fits to the 2PM and the 4PM. (A) Histograms of the residuals from a total of 106,320 data points acquired with the 22 protocols (Table 1) at three temperatures. Mean values plus/minus one standard deviation were 0.000386 ± 0.0118 (2PM, red) and − 0.000021 ± 0.0028 (4PM, blue). Systematic improvements obtained with the 4PM were particularly evident for MT-prepared acquisitions and for GS-experiments, which is exemplarily shown for protocols 6 (B) and 14 (C), respectively.