Table 1 Baseline characteristics of patients with cancer and healthy controls.
Patients with cancer (n = 19) | Healthy controls (n = 128) | P | |
|---|---|---|---|
Gender, male | 12 (63.2) | 65 (50.8) | 0.45* |
Age, mean (SD) | 12.1 (4.2) | 10.7 (4.2) | 0.18$ |
Caries | 5 (26.3) | 49 (38.3) | 0.45* |
Gingivitis | 3 (15.8) | 35 (27.3) | 0.40£ |
Washable plaque | 9 (47.4) | 72 (56.2) | 0.63* |
Aphthae | 0 (0.0) | 2 (1.6) | 1£ |
Candidiasis | 0 (0.0) | 1 (0.8) | 1£ |
Xerostomia | 3 (15.8) | 0 (0.0) | 0.002£ |
Abnormal mucosa | 2 (10.5) | 6 (4.7) | 0.28£ |
Salivary flow rate, mean (SD), ml/min | 1.13 (0.93) | 1.04 (0.73) | 0.62$ |
IFN-γ, median (IQR), pg/ml | 3.1 (1.7, 4.2) | 1.1 (0.7, 2.7) | 0.001# |
IL-1α, median (IQR), pg/ml | 1892 (796, 2507) | 756 (398, 1472) | 0.013# |
IL-1β, median (IQR), pg/ml | 44.5 (12.4, 138) | 16.1 (7.7, 36.6) | 0.062# |
IL-4, median (IQR), pg/ml | 1.7 (1.3, 2.5) | 1.4 (0.9, 2.0) | 0.068# |
IL-5, median (IQR), pg/ml | 1.3 (0.7, 2.4) | 0.9 (0.6, 1.3) | 0.063# |
IL-6, median (IQR), pg/ml | 3.8 (2.1, 6.2) | 2.9 (1.4, 8.1) | 0.40# |
IL-8, median (IQR), pg/ml | 589 (179, 956) | 282 (147, 609) | 0.078# |
IL-10, median (IQR), pg/ml | 16.0 (7.8, 29.0) | 7.6 (4.3, 11.8) | 0.003# |
IL-13, median (IQR), pg/ml | 13.9 (6.5, 19.9) | 9.0 (3.2, 18.9) | 0.18# |
IP-10, median (IQR), pg/ml | 29.9 (18.7, 93.1) | 52.6 (17.7, 106) | 0.70# |
TNF, median (IQR), pg/ml | 12.5 (9.8, 20.1) | 7.7 (4.4, 13.1) | 0.011# |
VEGF-A, median (IQR), pg/ml | 173 (124, 313) | 164 (88.4, 256) | 0.17# |
pH, mean (SD) | 7.8 (0.7) | n.a. | n.c. |
