Table 5 Results of multiple linear regression analyses of cytokine levels in patients with cancer 3 and 6 months after diagnosis compared with those at diagnosis represented as geometric mean ratios with 95% confidence intervals (coefficients of the models) and the corresponding P values.

From: Comparative analysis of salivary cytokine profiles in newly diagnosed pediatric patients with cancer and healthy children

Cytokine

Children

Adolescents

 

3 months versus at diagnosis

6 months versus at diagnosis

3 months versus at diagnosis

6 months versus at diagnosis

IFN-γ

1.11 (0.48, 2.57), P = 0.80

0.78 (0.33, 1.83), P = 0.56

1.02 (0.45, 2.35), P = 0.95

0.65 (0.27, 1.55), P = 0.32

IL-1a

0.61 (0.29, 1.28), P = 0.18

0.46 (0.22, 0.99), P = 0.046

0.65 (0.31, 1.35), P = 0.24

0.53 (0.24, 1.14), P = 0.099

IL-1β

1.21 (0.42, 3.46), P = 0.71

0.49 (0.17, 1.44), P = 0.19

0.69 (0.25, 1.95), P = 0.47

0.32 (0.11, 0.96), P = 0.043

IL-4

1.09 (0.66, 1.80), P = 0.73

0.98 (0.59, 1.63), P = 0.94

1.22 (0.75, 2.00), P = 0.41

0.86 (0.51, 1.44), P = 0.55

IL-5

1.25 (0.67, 2.30), P = 0.47

1.05 (0.56, 1.96), P = 0.88

1.35 (0.74, 2.47), P = 0.32

1.08 (0.57, 2.05), P = 0.81

IL-6

4.25 (1.32, 13.8), P = 0.018

0.83 (0.25, 2.72), P = 0.75

1.63 (0.51, 5.18), P = 0.40

0.50 (0.15, 1.68), P = 0.25

IL-8

0.93 (0.48, 1.82), P = 0.83

0.53 (0.27, 1.06), P = 0.070

0.69 (0.36, 1.34), P = 0.26

0.40 (0.20, 0.79), P = 0.011

IL-10

1.75 (0.87, 3.54), P = 0.11

0.90 (0.44, 1.84), P = 0.76

2.65 (1.33, 5.29), P = 0.008

0.86 (0.41, 1.79), P = 0.67

IP-10

4.24 (1.19, 15.1), P = 0.027

1.88 (0.51, 6.88), P = 0.33

2.55 (0.73, 8.93), P = 0.14

1.99 (0.53, 7.53), P = 0.30

TNF

1.33 (0.68, 2.61), P = 0.39

0.69 (0.35, 1.37), P = 0.28

1.23 (0.63, 2.38), P = 0.53

0.61 (0.31, 1.23), P = 0.16

VEGF-A

0.87 (0.41, 1.83), P = 0.70

0.58 (0.27, 1.23), P = 0.15

0.86 (0.41, 1.78), P = 0.67

0.53 (0.25, 1.15), P = 0.10

IL-13

1.33 (0.64, 2.78), P = 0.43

1.06 (0.50, 2.24), P = 0.87

1.69 (0.82, 3.49), P = 0.15

1.03 (0.48, 2.22), P = 0.93

  1. Separate linear mixed-effects models were fitted for each cytokine. A nested design was employed to obtain separate estimates for children and adolescents. All regression models were adjusted for sex, age, gingivitis, caries, salivary flow rate, and pH.
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