Fig. 5 | Scientific Reports

Fig. 5

From: Comprehensive exploration of programmed cell death landscape in lung adenocarcinoma combining multi-omic analysis and experimental verification

Fig. 5

Comprehensive Exploration of the TME in LUAD. (A) The distribution of stromal score, immune score and ESTIMATE score between the high- and low-CDI group calculated via the ESTIMATE algorithm. (B) The distribution of the infiltration score of B cells, Dentritic cells, Macrophages, Neutrophils, CD4 T cells, and CD8 T cells calculated via the TIMER algorithm. (C) The distribution of the infiltration score of 22 different immune cells calculated via the CIBERSORT algorithm. (D) The distribution of the infiltration score of 28 different immune cells calculated via the ssGSEA algorithm. (E) The difference of M1/M2 ratio between the high- and low-CDI group. (F) The correlation between the CDI and M1/M2 ratio. (G) UMAP plot visualized all cell types from the 11 LUAD patients in GSE131907. (H) UMAP plot exhibited the distribution of CDI in all the cell types. (I) Scatter plot exhibited the distribution of CDI across each cell type in detail. (J) Bubble plot revealed the expression levels of all 14 signature PCD-DEGs in each cell type.

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