Fig. 1 | Scientific Reports

Fig. 1

From: Cryo-EM structure of the calcium-sensing receptor complexed with the kokumi substance γ-glutamyl-valyl-glycine

Fig. 1

Cryo-EM map of the CaSR/γ-EVG complex. (a) Overall density map of CaSR (left) and cartoon of the model of CaSR in an active form (PDB: 7m3G) (right). CaSR is composed of a VFT domain, a CRD, and a 7TM domain. (b) Focus-refined map of the VFT domain of CaSR. Stick model of γ-EVG (orange) is overlaid with the cryo-EM density. (c) Chemical structure of γ-EVG. Cryo-EM cryo-electron microscopy, CaSR calcium-sensing receptor, γ-EVG γ-glutamyl-valyl-glycine, VFT Venus flytrap, CRD cysteine-rich domain, 7TM seven-transmembrane.

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