Fig. 2
γ-EVG recognition CaSR. (a) Interactions between CaSR and γ-EVG. Hydrogen bonds are shown as green dotted lines using ChimeraX46. CaSR is shown as a cartoon model (cyan) and the side chains of residues that interact with γ-EVG are shown as stick models (orange). (b) Superimposed models of CaSR/γ-EVG (cyan) and CaSR/L-Trp (PDB: 7M3G) (gray) based on the structure of CaSR. Residues within 4 Å of L-Trp are labeled and shown as stick models. γ-EVG and L-Trp are also shown as stick models (orange and gray). (c) Surface model of CaSR around γ-EVG (orange). The electrostatic potential is indicated by color (red for negative potential through white to blue for positive potential). CaSR calcium-sensing receptor, γ-EVG γ-glutamyl-valyl-glycine.
