Fig. 1 | Scientific Reports

Fig. 1

From: Head and neck tumor organoid grown under simplified media conditions model tumor biology and chemoradiation responses

Fig. 1

Morphological and pathological recapitulation of patient-derived organoids with matched tumor sources. (A) Summary of clinical sample acquisition and subsequent PDO establishment. (B) Pie chart illustrating the categories of PDO establishment status among stages. (C) H&E staining of matched surgical tissue and PDOs for Pt #003 and Pt #011. (D) Pathological feature of elongated pseudopodia in matched surgical tissue and PDOs for Pt #011. (E) Pathological feature of keratin pearl in matched surgical tissue and PDOs for Pt #012. (F) KRT 10/13 IF staining in matched surgical tissue and PDOs for Pt #003. (G) IHC staining for p16 as a surrogate marker for HPV status diagnosis for HNSCC patients (Pt #015 and Pt #021).

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