Fig. 3 | Scientific Reports

Fig. 3

From: Head and neck tumor organoid grown under simplified media conditions model tumor biology and chemoradiation responses

Fig. 3

Genetic concordance between PDOs and surgical tissue FFPEs revealed by whole exome sequencing. (A) Single nucleotide variants (SNV) and Copy number variant (CNV) calls and similarity between matched PDO and FFPE pairs. For SNV calls, Jaccard similarity is based on individual variant calls. For CNV calls, Szymkeiwicz-Simpson similarity is reported based on genomic regions of copy number variation. (B) Evaluation of potential major genetic mutations that replicate between matched FFPE and PDO samples.

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