Fig. 4 | Scientific Reports

Fig. 4

From: N6-methyladenosine (m6A)-forming enzyme METTL3 controls UAF1 stability to promote inflammation in a model of colitis by stimulating NLRP3

Fig. 4

NLRP3 and IL-1β are potential targets of UAF1 in the mouse model of colitis. The results of microarray analysis are visualized through a heat map depicting differentially expressed genes and enriched pathways (A), a volcano map highlighting gene expression changes (B), GSEA enrichment graph illustrating the NLRP3 inflammasome signaling pathway (C), and NLRP3 protein expression in the colon tissue of mice with colitis (D). The experimental groups include the Control (DSS-induced colitis group) and UAF1i (DSS-induced colitis treated with UAF1 inhibitor group); **P < 0.01 compared with Control group (n = 3).

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