Fig. 6 | Scientific Reports

Fig. 6

From: N6-methyladenosine (m6A)-forming enzyme METTL3 controls UAF1 stability to promote inflammation in a model of colitis by stimulating NLRP3

Fig. 6

The regulation of NLRP3 could control the effects of UAF1 on inflammation in RAW264.7 macrophages by LPS + ATP. UAF1 and NLRP3 protein expression levels (A); IL-1β, IL-6, TNF-α, and IFN-γ levels (B, C, D and E). N3, NLRP3 agonist; N3 i, NLRP3 inhibitor; **P < 0.01 compared with negative or Si-nc group; ##P < 0.01 compared with UAF1 or Si-UAF1 group (n = 6).

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