Fig. 8 | Scientific Reports

Fig. 8

From: N6-methyladenosine (m6A)-forming enzyme METTL3 controls UAF1 stability to promote inflammation in a model of colitis by stimulating NLRP3

Fig. 8

M6A promoted UAF1 stability by METTL3. A prediction score distribution along the query sequence (A), relative enrichment of UAF1 compared between IgG and m6A under negative and SI-METTL3 conditions (B), UAF1 mRNA expression over time for IgG and m6A in SI-METTL3 group (C), six mutation sites in the CDS region (D), mRNA levels of UAF1 at six different sites under negative and SI-METTL3 conditions (E), luciferase activity on wild-type and mutant UAF1 (F), and relative enrichment of UAF1 compared between IgG and m6A at the six sites (G). *P < 0.05 compared with IgG/Negative/METTL3 group; **P < 0.01 compared with IgG/Negative/METTL3 group.

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