Table 1 List of RDRP protein residues participating in intermolecular interactions with phytochemicals.

RDRP-echinacoside

Arg⁷³¹(2), Arg⁷³⁹, Ile⁷⁹⁹, Ser⁷⁹⁸, Trp⁷⁹⁷, Arg⁷⁹⁴, Tyr⁷⁶⁸, Cys⁷¹¹

Tyr⁶⁰⁹, Leu⁷³⁶, Ile³⁴², Trp⁸⁰⁵, Pro⁷⁴⁴, Leu⁵¹³, Met⁷⁶³, Tyr⁷⁶⁰, Ile⁷⁹⁹, Trp⁷⁹⁷, Tyr⁷⁶⁸, Leu⁷⁶⁷, Cys⁷¹¹

Ser⁶⁶³, His⁸⁰⁰, Ser⁷⁹⁸, Thr⁷⁹⁶, Thr⁷⁹⁵, Ser⁷¹², His⁷¹³

Trp⁷⁹⁷

Arg⁷³¹, Arg⁷³⁹, Arg⁷⁹⁴

Ash⁶⁶⁵, Glu⁷³⁵

Gly⁸⁰¹

RDRP-rutin

Ser⁶⁶³, Ile⁷⁹⁹, Tyr⁶⁰⁹, Gln⁶⁰⁵, Arg⁴⁸³

Ile⁷⁹⁹, Trp⁷⁹⁷, Ile⁴⁷⁵, Tyr⁴⁷⁷, Met⁴⁷⁸, Cys⁷¹¹, Tyr⁶⁰⁹, Val⁶⁰⁶

Ser⁶⁶³, His⁸⁰⁰, Ser⁷⁹⁸, Thr⁶⁰⁸, Gln⁶⁰⁵

Lys⁴⁵⁸, Arg⁴⁷³

Lys⁴⁵⁸, Arg⁴⁷³, Arg⁴⁸³

Gly⁶⁶⁴, Gly⁶⁰⁴, Gly⁴¹¹

RDRP-echinacin

Arg⁴⁷³, Arg⁷³¹, Ser⁶⁶³(2), Cys⁷¹¹

Met⁷⁶³, Leu⁵¹³, Tyr⁶⁰⁹, Ile⁴⁷⁵, Leu⁷³⁶, Tyr⁷⁶⁸, Leu⁷⁶⁷, Trp⁸⁰⁵, Trp⁷⁹⁷, Ile⁷⁹⁹, Cys⁷¹¹

Thr⁷⁹⁶, Ser⁷⁹⁸, His⁸⁰⁰, Ser⁷¹², His⁷¹³, Ser⁶⁶³

Arg⁴⁷³, Lys⁴⁵⁸, Arg⁷³¹

Asp⁶⁶⁶, Ash⁶⁶⁵

Gly⁶⁶⁴, Gly⁸⁰¹

RDRP-cynaroside

Ser⁷⁹⁸, Ile⁷⁹⁹, Ser⁶⁶³(2), Ash⁶⁶⁵, Tyr⁶⁶⁸(2)

Trp⁷⁹⁷, Ile⁷⁹⁹, Tyr⁶⁰⁹, Met⁷⁶³, Tyr⁷⁶⁰, Cys⁷¹¹, Leu⁵¹³, Leu⁷⁶⁷, Tyr⁷⁶⁸, Leu⁷³⁶

Thr⁷⁹⁵, Thr⁷⁹⁶, Ser⁷⁹⁸, His⁸⁰⁰, Ser⁶⁶³, His⁷¹³

Arg⁷³¹

Arg⁷³¹, Arg⁷³⁹

Ash⁶⁶⁵, Asp⁶⁶⁶

Gly⁶⁶⁴

RDRP-G8O-G8L

Trp⁷⁹⁷, Arg⁷³¹

Ile³⁴², Trp⁷⁹⁷, Met⁷⁶³, Tyr⁷⁶⁰, Leu⁷³⁶, Tyr⁷⁶⁸, Leu⁷⁶⁷, Trp⁸⁰⁵, Leu⁵¹³, Leu⁵¹⁶, Cys⁷¹¹

His⁸⁰⁰, Ser⁷⁹⁸, Thr⁷⁹⁶, Thr⁷⁹⁵, His⁷¹³, Ser⁷¹²

Arg⁷³¹

Arg⁷³⁹

Glu⁷³⁵

Gly⁸⁰¹