Fig. 6 | Scientific Reports

Fig. 6

From: The superoxide dismutase mimetic TEMPOL modulates nicotine-induced hyperlocomotor activity and nicotine-taking behavior in male rats

Fig. 6

Effect of TEMPOL on nicotine mediated DA inhibition in the NAc. (A). Experimental timeline for nicotine injections in vivo and brain slice recordings. (B). Example current traces and colorplots from fast scan cyclic voltammetry experiments. Acute nicotine (100 nM) bath application reduces evoked NAc DA release in a saline injected rat. **P < 0.01 vs. BL. (C). In the saline injected rats, DA release was reduced by nicotine bath application regardless of presence of TEMPOL (3 mM). (D). The nicotine injected rats had increased sensitivity to nicotine-induced DA reductions if pretreated with TEMPOL. **P < 0.01 vs. Nicotine. BL = baseline and ns = no significance. Individual dots (ο) represent experiments from brain slices in 4 – 8 rats. Bar plots are presented as the mean ± SD. n = 4–8/group.

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