Table 1 Patients characteristics by fatigue grade at baseline (Month 0).

From: Hemodialysis employing molecular hydrogen (H2) enriched dialysis solution may improve dialysis related fatigue through impact on energy metabolism

Group

A

B

C

P-value

N(%)

25 (30.9%)

24(29.6%)

32(39.5%)

 

NRS on HD

5.56±1.32

2.75±0.44

0.43±0.50

0.000

NRS off HD

3.36±2.19

1.79±1.25

0.25±0.43

0.000

Age (years old)

73±12

63±11

66±11

0.019

Male (%)

15 (60.0%)

17 (70.8%)

28 (87.5%)

0.057

HD vintage (days)

3430±1811

4032±2974

4232±2554

0.529

Presence of DM (%)

10 (40.0%)

8 (33.3%)

12 (37.5%)

0.887

Past history of CVD (%)

10 (40.0%)

5 (20.8%)

10 (31.2%)

0.347

BMI

22.0±3.3

21.9±2.9

23.2±4.5

0.406

DW (kg)

59.2±13.4

60.0±13.8

65.0±17.0

0.290

Fat volume (kg)

16.1±8.2

12.0±5.9

15.2±10.0

0.239

Muscle volume (kg)

19.1±5.0

19.9±7.5

22.5±6.5

0.155

ECV/TBW (%)

47.5±4.3

46.6±4.7

44.7±3.1

0.053

Pre HD MBP (mmHg)

102±15

105±14

102±13

0.720

Post HD MBP (mmHg)

99±14

98±12

100±12

0.807

MMSE

27±3

26±2

27±3

0.258

Hemoglobin (g/dL)

11.1±1.3

10.7±1.2

11.0±1.0

0.554

Albumin (g/dL)

3.5±0.4

3.8±0.3

3.7±0.3

0.118

CRP (mg/dL)

0.19±0.20

0.23±0.49

0.20±0.26

0.943

ANP (pg/mL)

77.3±52.6

62.3±36.3

55.1±37.4

0.149

cfDNA (unit)

3.62±0.75

3.41±0.85

3.58±0.81

0.628

MPO-DNA (unit)

2.80±2.02

2.76±1.72

2.51±1.10

0.760

  1. Group-A; NRS 4 or more at baseline (Month 0), Group-B; NRS 2 or 3 at baseline (Month 0), Group-C: NRS 0 or 1 at baseline (Month 0).
  2. NRS: Numerical Rating Scale (0 to 10); HD: hemodialysis; DM: Diabetes Mellitus; CVD: cardiovascular disease; angina pectoris, and myocardial infarction; BMI: Body mass index; DW: dry weight; ECF: Extracellular fluid; TBW: Total body water; MBP: Mean blood pressure; MMSE: mini-mental scale examination; CRP: C-reactive protein; ANP: human atrial natric peptide; cfDNA: cell-free DNA; MPO-DNA: myeloperoxidase and DNA complex (data is expressed as mean +/- standard deviation).