Table 2 Patient characteristics of sub-group of Group-A: baseline (Month 0) and end of observation (Month 12).

From: Hemodialysis employing molecular hydrogen (H2) enriched dialysis solution may improve dialysis related fatigue through impact on energy metabolism

Sub-group (n)

A1 (n=11)

A2 (n=14)

A1 vs. A2

(M0)

Period

Month 0

Month 12

P-value

M0

M12

P-value

P-value

NRS on HD day

6.36±1.12

4.54±2.54

0.024

4.92±1.14

2.78±2.19

0.002

0.004

NRS on HD-free day

5.45±1.19

2.81±2.78

0.040

1.71±0.99

1.21±2.04

0.265

0.000

Age (yo)

75±11

  

72±13

  

0.522

Male (%)

4 (36.4%)

  

11 (78.6%)

  

0.057

HD vintage (days)

4067±2316

  

2951±1218

  

0.168

Presence of DM (%)

4 (36.4%)

  

6 (42.9%)

  

0.887

Past history of CVD (%)

5 (45.5%)

  

5 (35.7%)

  

0.347

BMI

22.1±4.3

  

21.9±2.4

  

0.904

DW (kg)

54.7±15.7

55.2±15.0

0.470

62.8±10.0

61.3±11.0

0.072

0.137

Fat mass (kg)

16.3±10.8

17.9±8.1

0.284

17.6±6.4

13.8±5.5

0.048

0.925

Skeletal muscle mass (kg)

16.4±5.1

15.6±5.5

0.238

21.2±4.0

22.9±4.3

0.029

0.027

ECV/TBW (%)

49.1±4.4

50.3±4.7

0.110

49.3±4.0

47.2±3.3

0.017

0.144

Pre HD MBP (mmHg)

104±19

100±7

0.649

100±11

101±17

0.865

0.524

Post HD MBP (mmHg)

96±14

98±14

0.817

101±14

99±14

0.571

0.422

MMSE (arbitrary)

27±4

27±4

0.680

27±3

27±4

0.523

0.725

  1. A1; chronic persistent fatigue (NRS 4 or more) on both HD and HD-free days at baseline (Month 0), A2; as having fatigue (NRS 4 or more) only on HD days at baseline (Month 0).
  2. NRS: Numerical Rating Scale (0 to 10); HD: hemodialysis; CVD: cardiovascular disease; BMI: Body mass index; DW: Dry weight; ECF: Extracellular fluid; TBW: Total body water; MBP: Mean blood pressure; MMSE: mini-mental scale examination; (Data is expressed as mean +/- standard deviation)