Fig. 4
From: The liver proteome of individuals with a natural UGT2B17 complete deficiency
Enzymes of energy metabolic pathways divergent in UGT2B17-deficient livers. Glucose-6-phosphate is a central metabolite produced by the phosphorylation of glucose by glucokinase (GCK). Its fate is diverse, feeding glycolysis, the pentose phosphate pathway (PPP) and the uronic acid pathway. Lower GCK and higher hexose 6-phosphate dehydrogenase (H6PD) and transketolase (TKT) expression could favor the pentose phosphate pathway and production of NADPH. Serine, glycine and NADH production catalyzed by 3-phosphoglycerate dehydrogenase (PHGDH) is reduced. GCK: glucokinase; H6PD: hexose 6-phosphate dehydrogenase; UGGT1: UDP-glucose glycoprotein transferase 1; TKT: transketolase. PC: pyruvate carboxylase; TCA: tricarboxylic acid cycle. Created with BioRender.com.
