Table 1 Significantly mutated genes (SMGs) in cDLBCL. No. Samples is the number of dogs with at least one mutation in a gene, and no. Mutations is the total number of somatic non-synonymous mutations found in a gene. The R package dNdScv (v.0.0.1.0), which is designed to detect genes under positive selection in cancer, was used to compute the global p and q values per gene. P-values were obtained utilizing the likelihood-ratio test, while q-values were obtained using Benjamini-Hodgberg’s multiple testing correction. Genes with a q-value ≤ 0.05 were considered to be under significant positive selection, and are shown in this table.
Gene name | No. samples | No. mutations | p-value | q-value |
|---|---|---|---|---|
TRAF3 | 25 | 43 | < 0.000 | < 0.000 |
POT1 | 13 | 14 | < 0.000 | < 0.000 |
SETD2 | 10 | 12 | < 0.000 | 0.003 |
TBL1XR1 | 8 | 11 | < 0.000 | 0.004 |
FBXW7 | 13 | 19 | < 0.000 | 0.022 |
