Fig. 3 | Scientific Reports

Fig. 3

From: To investigate the tumor promotion role of PLOD3 in colorectal cancer and its potential as a prognostic biomarker and therapeutic target

Fig. 3

Prognostic model construction and validation: differential expression, survival analysis, and machine learning performance in CRC cohorts. (A) Differential expression of fibroblast scores across various groups in the TCGA and GSE14333 datasets; (B) Results of univariate analysis from the TCGA dataset; (C) Multivariate Cox analysis of model genes; (D) Calculation of the C-index for different datasets using 36 machine learning methods; (E) Kaplan-Meier (KM) curves and Receiver Operating Characteristic (ROC) analysis for the TCGA, GSE39582, GSE17538, GSE33113, GSE14333, GSE38832, and Meta datasets; (F) Differential expression analysis of model genes in normal and tumor samples within the TCGA dataset.

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