Fig. 8 | Scientific Reports

Fig. 8

From: To investigate the tumor promotion role of PLOD3 in colorectal cancer and its potential as a prognostic biomarker and therapeutic target

Fig. 8

PLOD3 is significantly upregulated in tumor cells, promoting cell migration and invasion. (A) High expression levels of PLOD3 mRNA in CRC cells. (B,C) Elevated protein levels of PLOD3 in CRC cells. The original gel is shown in supplementary Fig. 1. (D) qPCR validation of the knockdown efficiency of PLOD3. (E,F) Reduced expression of PLOD3 significantly inhibited the invasive capabilities of SW1116 and Caco2 cells. (G,H) Suppression of PLOD3 expression significantly decreased the migratory capacity of SW1116 and Caco2 cells. **p < 0.01, ***p < 0.001, ****p < 0.0001, #1 Results of the first experiment (The results of the second experiment #2 are uploaded as Supplementary Fig. 2.).

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