Fig. 3

BRCC3 deficiency alleviates alcoholic liver steatosis and injury. WT and Brcc3^−/− mice were subjected to chronic-plus-binge ethanol feeding for 10 days (N = 3–9). (A) Liver samples were stained with H&E or ORO, and ORO-positive areas were quantified. Scale bar, 100 μm. (B) Liver injury was quantified by measuring serum ALT. (C) Relative mRNA levels of hepatic pro-inflammatory cytokines. Data are presented as mean ± SEM; *P < 0.05, **P < 0.01, ***P < 0.001; two-tailed unpaired t-test.