Fig. 4 | Scientific Reports

Fig. 4

From: Knockdown of CCNB2 inhibits the tumorigenesis of gastric cancer by regulation of the PI3K/Akt pathway

Fig. 4

Knockdown of CCNB2 inhibits the proliferation of GC cells in vivo. (A-C) MKN-45 and CCNB2-knockdown MKN-45 cells, as well as HGC-27 and CCNB2-overexpressing HGC-27 GC cells, were subcutaneously injected into mice to assess tumor formation and evaluate tumor volume at days 7, 14, and 21 post-injection. Subsequently, the mice were euthanized, and tumors were harvested for analysis. (B-D) Immunohistochemistry (IHC) was employed to quantify expression levels of CCNB2 and proliferating cell nuclear antigen (PCNA) in (B) CCNB2-knockdown MKN-45 cells and (D) CCNB2-overexpressing HGC-27 cells. bar = 100 μm.

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