Fig. 1
From: Perinatal obesity primes the hepatic metabolic stress response in the offspring across life span
High-fat diet during pregnancy and early life leads to an obese phenotype in early life without signs of steatosis. (a) Scheme of the animal model in the present study: the perinatal obesity group received a high-fat diet (HFD) pre-gestationally, during pregnancy, and lactation. Offspring were weaned at postnatal day (P) 21 and either sacrificed or kept on standard diet (SD) until late adulthood (around 1.5 years). The control group was fed with SD. (b) Offspring of perinatal obesity display an increased bodyweight (n = 9) compared to the control group (n = 6). (c) Weight differences between the HFD group (n = 9) and control group (n = 7) diminish in late adulthood. (d) H&E histological analysis reveals no signs of steatosis in early life (SD n = 7, HFD n = 11). (e) H&E staining and analysis confirms no significant steatosis in late adulthood (SD n = 7, HFD n = 9). Data are presented as mean ± standard error of the mean (SEM). T-Test and Mann–Whitney-U-test were performed for statistical analysis of two groups and Fisher’s exact test and chi-square test were used for contingency tables. p < 0.05 was considered statistically significant and marked as *.
