Table 4 Relationships between the left substantia nigra DAT uptake, perfusion in the left supramarginal or angular gyrus, and AQ scores.

		Model 1		Model 2		Model 3
Group	Predictor	B	P value	B	P value	B	P value
Overall lvPPA	Left substantia nigra DAT uptake	0.40	0.023	0.33	0.057	0.46	0.014
	Left supramarginal gyrus perfusion	0.50	0.010	0.37	0.049
	Left angular gyrus perfusion	0.55	0.006			0.37	0.024
lvPPA^A+	Left substantia nigra DAT uptake	0.46	0.037	0.37	0.150	0.38	0.134
	Left supramarginal gyrus perfusion	0.34	0.183	0.16	0.559
	Left angular gyrus perfusion	0.37	0.200			0.18	0.534
lvPPA^A−	Left substantia nigra DAT uptake	0.79	0.039	−0.23	0.558	0.08	0.873
	Left supramarginal gyrus perfusion	1.24	0.002	1.48	0.030
	Left angular gyrus perfusion	1.02	0.012			0.96	0.119

The results are based on the general linear models for AQ scores after controlling for age, sex, and education. Model 1 used left substantia nigra DAT uptake, left supramarginal gyrus perfusion, or left angular gyrus perfusion as a predictor. Model 2 included left substantia nigra DAT uptake and left supramarginal gyrus perfusion as predictors, while Model 3 included left substantia nigra DAT uptake and left angular gyrus perfusion as predictors. Abbreviations: AQ, aphasia quotient; B, standardized beta coefficient; DAT, dopamine transporter; lvPPA^A−, amyloid-negative logopenic primary progressive aphasia; lvPPA^A+, amyloid-positive logopenic primary progressive aphasia.

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