Fig. 3

Survival analysis of ADAM12 across pan-cancer from TCGA database. (A) Survival map depicting ADAM12 gene expression across pan-cancer types. (B) Forest plots illustrating the correlations between OS/DSS and ADAM12 expression across 38 cancer types. (C) ADAM12 expression, survival time, and status in the TCGA-GBMLGG dataset. Kaplan–Meier survival estimates for patients at all grades, along with ROC curves and AUC values for ADAM12 at 1-, 3-, and 5- years in the TCGA-GBMLGG dataset. (D) Kaplan–Meier analyses of the association between ADAM12 expression and OS in GBMLGG, Pan-kidney cohort KIPAN (KICH + KIRC + KIRP), LIHC, BRCA, KIRC, UVM, OV, MESO, KIRP, ACC and LUAD. (E) P-values, risk coefficients (HR), and confidence intervals were analyzed through univariate and multivariate Cox regression. A nomogram predicting 1-, 2- and 3-years overall survival of glioma patients. Calibration curves for the overall survival nomogram model in the discovery group. The dashed diagonal line represents the ideal model, while the blue, red, and orange lines represent the observed nomogram at 1-, 2-, and 3- years, respectively.