Fig. 1 | Scientific Reports

Fig. 1

From: Premature ageing of lung alveoli and bone marrow cells from Terc deficient mice with different telomere lengths

Fig. 1

Generation of one strain of CAST/EiJ mice mutated in the Terc gene. Panel A. Breeding scheme and nomenclature of each generation. Heterozygous mice G5 were intercrossed to obtain G6: CT-Terc+/+, CT-Terc+/− and CT-Terc−/−. In parallel, C57BL/6J Terc+/− animals were crossed to obtain C57-Terc+/+, C57-Terc+/− and C57-Terc−/− animals. Panel B. Weight of the animals generated in the two genetic backgrounds (mice from 2 months to 10 months). Panel C. Telomere size (expressed as T/S ratio) of the mice strains with different Terc genotypes and genetic background at several ages (Time 0 to 24 months), determined from ear tissues. Linear regression analysis was used to assess the rate of telomere shortening with age. The Pearson correlation coefficient and linear regression equation were calculated (Y = −0,01723*X + 1,147) and were significant for CT-Terc+/-, p < 0.01.

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