Fig. 7
Analysis of hematopoietic progenitor cells inTerc mutant mice. Panel (A) Flow cytometry analysis of the megakaryocyte-erythroid progenitors. This quantification was assessed within the Lin−Sca1−cKit+ population (n = 65–138). Panel (B) Clonogenic potential studies in the characterized mouse strains. Left panel, CFCs per 104 BM cells (n = 21–45). Right panel, CFC numbers per 104 LSK cells (n = 18–43). Methylcellulose cultures were maintained for 7 days and CFC numbers are expressed as mean ± SD per ten thousand cells. Data were obtained from animals of the different ages analyzed in each strain and are expressed as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001 vs. wild type mice by ANOVA and Dunnett´s comparison test.
