Table 4 Association of 1-SD increment in AD polygenic score with cognitive function in ADNI.
Cognitive functions | Cognitive normal | Mild cognitive impairment | ||||||
|---|---|---|---|---|---|---|---|---|
Model 1 | Model 2 | Model 1 | Model 2 | |||||
Beta (SE) | P value | Beta (SE) | P value | Beta (SE) | P value | Beta (SE) | P value | |
Mini-Mental State Exam, MMSE | − 0.074 (0.026) | 4.89E−03 | − 0.067 (0.030) | 0.03 | − 0.218 (0.041) | 1.46E−07 | − 0.076 (0.047) | 0.10 |
Alzheimer Disease Assessment Scale 11 | 0.089 (0.029) | 2.63E−03 | 0.079 (0.033) | 0.02 | 0.252 (0.041) | 2.32E−09 | 0.118 (0.047) | 0.01 |
Alzheimer Disease Assessment Scale 13 | 0.094 (0.032) | 4.01E−03 | 0.082 (0.037) | 0.03 | 0.254 (0.042) | 3.67E−09 | 0.109 (0.048) | 0.02 |
Montreal Cognitive Assessment | − 0.067 (0.038) | 0.08 | − 0.050 (0.043) | 0.24 | − 0.252 (0.047) | 1.12E−07 | − 0.094 (0.053) | 0.08 |
Functional Assessment Questionnaire | 0.057 (0.027) | 0.03 | 0.053 (0.030) | 0.08 | 0.211 (0.044) | 1.92E−06 | 0.055 (0.050) | 0.27 |
ADNI memory summary score | − 0.084 (0.042) | 0.05 | − 0.073 (0.048) | 0.13 | − 0.226 (0.039) | 2.06E−08 | − 0.085 (0.045) | 0.06 |
ADNI executive function score | − 0.061 (0.043) | 0.16 | − 0.049 (0.048) | 0.31 | − 0.106 (0.040) | 7.27E−03 | 0.005 (0.046) | 0.90 |
ADNI language summary score | − 0.035 (0.042) | 0.41 | − 0.054 (0.048) | 0.26 | − 0.157 (0.040) | 8.55E−05 | − 0.066 (0.047) | 0.15 |
ADNI visuospatial summary score | − 0.013 (0.037) | 0.73 | − 0.016 (0.042) | 0.70 | − 0.066 (0.035) | 0.06 | 0.023 (0.041) | 0.58 |
