Fig. 5

(a) The Venn diagram shows unique and shared proteins identified in SaEVs and non-EV secretions. (b) Bar chart showing the different subcellular locations and percentages of the proteins identified in SaEVs. (c) The Clusters of Orthologous Groups (COGs) categories analysis. Adjacent numbers on the bar charts denote the total proteins identified per category. A: RNA processing and modification; C: Energy production and conversion; D: Cell cycle control, cell division, and chromosome partitioning; E: Amino acid transport and metabolism; F: Nucleotide transport and metabolism; G: Carbohydrate transport and metabolism; H: Coenzyme transport and metabolism; I: Lipid transport and metabolism; J: Translation, ribosomal structure, and biogenesis; K: Transcription; L: Replication, recombination, and repair; M: Cell wall/membrane/envelope biogenesis; N: Cell motility; O: Post-translational modification, protein turnover, and chaperones; P: Inorganic ion transport and metabolism; Q: Secondary metabolites biosynthesis, transport, and catabolism; S: Function unknown; T: Signal transduction mechanisms; U: Intracellular trafficking, secretion, and vesicular transport; V: Defense mechanisms; Z: Cytoskeleton. (d) Protein-protein interaction of cluster 7 (Supplementary Tables 3, 14 proteins) showing the most significant terms: cell wall organisation (purple), penicillin-binding (green), and beta-lactamase resistance (red).