Table 1 Selection of virulent proteins included in M5512B Staphylococcus aureus-derived extracellular vesicles.
Gene Symbol | Gene Name | Uniprot access num. | Biological process | Molecular Function | Conserved EV core protein |
|---|---|---|---|---|---|
agrB | Accessory gene regulator protein B | Q2FWM7 | Proteolysis, quorum sensing | Peptidase activity | |
alt | Bifunctional autolysin | Q2FZK7 | Peptidoglycan catabolic activity | Amidase activity | yes |
clfB | Clumping factor B | Q2FUY2 | Virulence | ||
clpC | ATP-dependent Clp protease ATP-binding subunit ClpC | Q2G0P5 | Response to stress, virulence | ATP binding | |
coa | Coagulase | Q2G1D3 | |||
crtP | 4,4’-diaponeurosporene oxygenase | Q2FV57 | Carotenoid biosynthesis, virulence | ||
cvfB | Conserved virulence factor B | Q2FYP3 | |||
dltD | Protein DltD | Q2FZW3 | lipoteichoic acid biosynthetic process | yes | |
eno | Enolase | Q2G028 | Glycolysis, virulence | Lyase | yes |
epbS | Elastin-binding protein | Q2FYF1 | yes | ||
fmtA | Teichoic acid D-alanine hydrolase | Q2FZK3 | response to antibiotic | hydrolase activity | |
ftnA | Bacterial non-heme ferritin | Q2FWZ8 | Iron storage | Oxidoreductase | yes |
ftsH | ATP-dependent zinc metalloprotease FtsH | Q2G0R0 | proteolysis | Metalloprotease | yes |
gapA1 | Glyceraldehyde-3-phosphate dehydrogenase | Q2G032 | glucose metabolic process | Oxidoreductase | yes |
hld | Delta-hemolysin | Q2FWM8 | Hemolysis, virulence | Toxin activity | yes |
hlgB | Gamma-hemolysin component B | Q2FVK1 | Hemolysis, virulence | Toxin activity | |
hlgC | Gamma-hemolysin component C | Q2FVK2 | Hemolysis, virulence | Toxin activity | |
hly | Alpha-hemolysin | Q2G1 × 0 | Hemolysis, virulence | Toxin activity | |
htrA | Serine protease HtrA-like | Q2FXJ6 | proteolysis | Serine protease | yes |
SAOUHSC_02241 | leukocidin-like protein 1 | Q2FWP0 | cytolylisis in another organism | ||
SAOUHSC_02243 | leukocidin-like protein 2 | Q2FWN9 | cytolylisis in another organism | ||
ltaS | Lipoteichoic acid synthase | Q2G093 | cell wall organization | metal ion binding | yes |
lytM | Glycyl-glycine endopeptidase LytM | O33599 | Proteolysis, cell wall organization | metalloendopeptidase activity | |
mgrA | HTH-type transcriptional regulator MgrA | Q2G0B1 | Response to stress | DNA-binding | |
mprF | Phosphatidylglycerol lysyltransferase | Q2G2M2 | response to antibiotic | aminoacyltransferase activity | |
pbp1 | Penicillin-binding protein 1 | Q2FZ94 | cell wall organization | penicillin binding | |
pbp3 | Penicillin-binding protein 3 | Q2FY21 | cell wall organization | penicillin binding | yes |
pbp4 | Penicillin-binding protein 4 | Q2G2 × 6 | Proteolysis, response to antibiotic | beta-lactamase activity | yes |
psmA1 | Phenol-soluble modulin alpha 1 peptide | P0C7Y1 | killing of cells of another organism | yes | |
psmA2 | Phenol-soluble modulin alpha 2 peptide | P0C7Z3 | killing of cells of another organism | yes | |
psmA4 | Phenol-soluble modulin alpha 4 peptide | P0C818 | killing of cells of another organism | yes | |
rny | Ribonuclease Y | Q2FZ08 | mRNA catabolic process | RNA endonuclease activity | |
saeS | Histidine protein kinase SaeS | Q2G2U1 | Virulence | phosphorelay sensor kinase activity | |
sarA | Transcriptional regulator SarA | Q2G2U9 | Transcription regulation | DNA-binding | |
sarS | HTH-type transcriptional regulator SarS | Q2G1N7 | response to stress | DNA binding | |
sarV | HTH-type transcriptional regulator SarV | Q2FVY9 | Virulence | DNA binding | |
sarX | HTH-type transcriptional regulator SarX | Q2G0D1 | Virulence | DNA binding | |
sbi | Immunoglobulin-binding protein Sbi | Q2FVK5 | Virulence | IgG binding | yes |
sdrC | Serine-aspartate repeat-containing protein C | Q2G0L5 | cell adhesion | ||
secA1 | Protein translocase subunit SecA 1 | O06446 | Protein transport | metal ion binding | yes |
selX | Enterotoxin-like toxin X | Q2G107 | |||
sl11 | Staphylococcal superantigen-like 11 | Q2G0 × 4 | Virulence | ||
sle1 | N-acetylmuramoyl-L-alanine amidase sle1 | Q2G0U9 | killing of cells of another organism | lytic endotransglycosylase activity | |
srtA | Sortase A | Q2FV99 | Proteolysis | metal ion binding | yes |
ssaA | Staphylococcal secretory antigen SsaA | Q2FV55 | Virulence | ||
ssaA2 | Staphylococcal secretory antigen ssaA2 | Q2G2J2 | Virulence | hydrolase activity | yes |
sspP | Staphopain A | Q2G2R8 | Proteolysis, virulence | cysteine-type peptidase activity | |
tcaA | Membrane-associated protein TcaA | Q2G2I1 | response to antibiotic | metal ion binding | yes |
traP | Signal transduction protein TRAP | Q2G2F3 | Virulence | ||
tuf | Elongation factor Tu | Q2G0N0 | translational elongation | GTP-binding | yes |
vraS | Sensor protein VraS | Q2FX08 | Two-component regulatory system | protein dimerization activity | yes |
