Fig. 11
Expression of UBE2N in the brains of TauP301S mice. (A) Differential expression of UBE2N and related genes in the cortex of control (n = 8) and TauP301S mouse brains (n = 8) was analyzed by RT-qPCR using GAPDH as a control. (B) UBE2N expression in the temporal cortex of the control (n = 8) and TauP301S mice (n = 8). (C) UBE2N expression in the hippocampi of control (n = 8) and TauP301S mice (n = 8). Positive staining for UBE2N was observed in the cortex (D) and hippocampus (E), and it colocalized with red-labeled NeuN in the cortex and hippocampus in immunofluorescence images. The scale bar for immunohistochemistry images is 50 μm, and the scale bar for cortical and hippocampal immunofluorescence images is 200 μm and 500 μm, respectively. All data from at least three independent experiments are presented as mean ± SEM. * p < 0.05, ** p < 0.01 with respect to the control group.
