Fig. 1 | Scientific Reports

Fig. 1

From: Protective effects of indole-3-propionic acid against TCP-induced hearing loss in mice by mitigating oxidative stress and promoting neutrophil recruitment

Fig. 1

IPA treatment reduced TCP-induced ABR threshold changes. (A) Schematic diagram of the experimental flow of the ABR test, (B) ABR test of the mice with different treatments, (C) ABR threshold plots at Click stimulation after 21 days of gavage in NC, 40 mg/kg IPA, 50 mg/kg TCP, 20 mg/kg IPA + 50 mg/kg TCP, and 40 mg/kg IPA + 50 mg/kg TCP groups, (D) ABR threshold plots at 8 kHz, 16 kHz, 32 kHz pure tone stimulation after 21 days of gavage in NC, 40 mg/kg IPA, 50 mg/kg TCP, 20 mg/kg IPA + 50 mg/kg TCP, and 40 mg/kg IPA + 50 mg/kg TCP groups. Data are represented the means  ±  SD, n = 8 for each group; **: p < 0.01 compared with control; ***: p < 0.001 compared with control; #: p < 0.05 compared with 50 mg/kg TCP group; ##: p < 0.01 compared with 50 mg/kg TCP group; ###: p < 0.001 compared with 50 mg/kg TCP group by one-way ANOVA with Bonferroni posthoc test.

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