Fig. 2 | Scientific Reports

Fig. 2

From: Protective effects of indole-3-propionic acid against TCP-induced hearing loss in mice by mitigating oxidative stress and promoting neutrophil recruitment

Fig. 2

IPA treatment reduced TCP-induced morphological damage of the cochlea. (A) H&E staining of HCs, SGNs, SV, SL in the basal turn of the cochlea after 21 days of gavage in corn oil, 40 mg/kg IPA, 50 mg/kg TCP, 20 mg/kg IPA + 50 mg/kg TCP, and 40 mg/kg IPA + 50 mg/kg TCP groups(corn oil as solvent, n = 3), (B) schematic structure of cochlea sections, (C) bar graph showing the average number of SGNs in the basal turn of the cochlea, (D) bar graph showing the average thickness of SV in the basal turn of the cochlea. Bar = 100 μm; Data represent the means  ±  SD; **: p < 0.01 compared with control; ***: p < 0.001 compared with control; #: p < 0.05 compared with 50 mg/kg TCP group; ##: p < 0.01 compared with 50 mg/kg TCP group; ###: p < 0.001 compared with 50 mg/kg TCP group; ####: p < 0.0001 compared with 50 mg/kg TCP group by one-way ANOVA with Bonferroni post hoc test.

Back to article page