Fig. 3 | Scientific Reports

Fig. 3

From: Human nasal turbinate stem cells with specific gene signatures (HAS2, CXCL1, KRTAP1-5, GSTT2B, and C4B) attenuate rheumatoid arthritis

Fig. 3

hNTSCs attenuate the development of arthritis in mice. (A) Arthritic scores and incidence in vehicle (PBS, n = 12), hNTSCs (1 × 106 cells/0.1 mL/mouse, n = 12) and methotrexate hydrate (MTX, 3 mg/kg, n = 12)-treated CIA mice. Mice were euthanized 8 weeks after primary immunization. (B) Serum levels of anti-CII-specific IgG1 and IgG2a were determined by ELISA. (C) Joint histology was assessed by staining with hematoxylin & eosin (original magnification, x40). (D) Micro-CT images of talus bone from vehicle- or hNTSCs-treated mice. The scatter dot plot shows the talus volume and surface. (E) Micro-CT images of subchondral femur bone from vehicle- or hNTSC-treated mice. Data are shown as the mean ± SD. ns not significant; *P < 0.05; **P < 0.01; ***P < 0.001.

Back to article page