Table 5 Pathways detected from the mapped genes in eQTL with the suggestively associated variants from meta-analysis for side effects after vaccination.
Symptoms | Minimum P-value in GWAS | Number of lead variants (P < 1 × 10−5) | Mapped genes in eQTL | Category | GeneSet | Number of genes in GeneSet | Number of overlapped genes | Adjusted P-value | Genes |
|---|---|---|---|---|---|---|---|---|---|
Pain | 1.89 × 10−9 | 51 | 238 | GOMF | MHC_CLASS_II_PROTEIN_COMPLEX_BINDING | 21 | 7 | 1.55 × 10−7 | MHC locus genes, ANXA11 |
Other 5 pathways including MHC locus genes (Table S9) | |||||||||
Redness | 1.97 × 10−10 | 37 | 184 | GOCC | GOLGI_APPARATUS | 1579 | 24 | 1.88 × 10−2 | MHC locus genes, 18 genes outside MHC locus** |
Other 4 pathways including MHC locus genes (Table S9) | |||||||||
Swelling | 6.85 × 10−9 | 37 | 229 | ND | |||||
Induration | 2.88 × 10−10 | 35 | 98 | GOMF | METALLOPEPTIDASE_ACTIVITY | 193 | 7 | 4.36 × 10−3 | DNPEP: ADAMTS9:ADAMTS16:ERAP1:ERAP2:LNPEP: THOP1 |
Another pathway (Table S9) | |||||||||
Itching | 1.18 × 10−14 | 40 | 134 | GOBP | PROTEIN_DNA_COMPLEX_SUBUNIT_ORGANIZATION | 203 | 8 | 7.75 × 10−3 | MHC locus genes, CENPK |
Other 3 pathways including MHC locus genes (Table S9) | |||||||||
Burning sensation | 2.63 × 10−9 | 29 | 66 | ND | |||||
Swelling of lymph nodes | 1.12 × 10−10 | 34 | 120 | ND | |||||
Fever ≥ 37.5 °C | 7.88 × 10−17 | 62 | 831 | GOBP | ADAPTIVE_IMMUNE_RESPONSE | 436 | 58 | 1.50 × 10− 21 | MHC locus genes, 30 genes outside MHC locus** |
Other 118 pathways including MHC locus genes (Table S9) | |||||||||
Fatigue | 7.34 × 10−9 | 39 | 317 | GOBP | REGULATION_OF_T_CELL_ACTIVATION | 364 | 21 | 9.86 × 10−8 | MHC locus genes, TPKB: CTLA4:PBRM1:GPNMB: LYN: SIT1:BMI1:CD6:CD5:CSK |
Other 54 pathways including MHC locus genes (Table S9) | |||||||||
Headache | 3.57 × 10−12 | 44 | 225 | ND | |||||
Muscle pain/myalgia | 2.22 × 10−10 | 60 | 214 | GOCC | PLASMA_MEMBRANE_PROTEIN_COMPLEX | 551 | 14 | 3.34 × 10−2 | VCAM1:KCNS3:STON1:ACVR2B: SNTG1:KCNJ11:ABCC8:SCN4B: SCN2B: CD3E: CD3D: CBL: GJD2:GRIN2A |
Any systemic symptom | 1.65 × 10−10 | 24 | 90 | ND | |||||
