Fig. 1
From: Neural mechanisms underlying strain preference behaviour and plasticity in mice
Social preference of mice towards same and other strains in normal-rearing and cross-fostering environments, demonstrating plasticity in preferences. (A) Mice were divided into two groups: normal-rearing and cross-fostering environments, represented by gray and white icons for C57 and KM mice, respectively. (B) In the normal-fostering environment, the offspring served as the control group (Ctl). The treatment groups included the cross-fostering environment with C57LD: KM and KMLD: C57. (C) Paradigm for strain preference in three-chamber social interaction of mice. (D–F) Statistical analysis of mice’s social interaction time in the three-chamber social interaction experiment with same and other strains. The black bars represent the same strain, while the white bars represent the other strain. Social interaction time (S) is shown. (D) statistical results for social behaviour in C57 mice under normal-fostering and cross-fostering conditions(Paired t-test, C57Ctl: SS vs. OS, t10 = 2.621, p = 0.0256, n = 11; C57LD: KM: SS vs. OS, t5 = 0.0273, p = 0.9788, n = 6). (E) KM mice under normal-fostering and cross-fostering conditions (Paired t-test, KMCtl: SS vs. OS, t7 = 6.074, p = 0.0005, n = 8; KMLD: C57: SS vs. OS, t10 = 0.5960, p = 0.5645, n = 11). (F) Time Spent in the middle chamber by Mice (Unpaired t-test, C57Ctl vs. C57LD: KM, t15 = 0.1784, p = 0.8636; KMCtl vs. KMLD: C57, t17 = 0.9873, p = 0.3374). Data are presented as means ± s.e.m, *p < 0.05, **p < 0.01, ***p < 0.001.
