Fig. 4
From: Neural mechanisms underlying strain preference behaviour and plasticity in mice
Attenuation of neuronal activity discrepancy in SUM, CA2, and PAG brain regions of C57LD: KM mice under cross-fostering social environment. (A) The lactating dam is of the KM strain. c-Fos neuronal fluorescence staining images with a scale of 1:100 μm. Ctl represents the control group, and the treatment groups include the same-strain (SS) and other-strain (OS) social interactions. Brain region localization: PFC (Bregma: 1.78 mm to -1.34 mm), BLA (Bregma: -1.34 mm to -1.58 mm), PIL (Bregma: -3.16 mm to -3.40 mm), SUM (Bregma: -2.80 mm to -3.08 mm), CA2 (Bregma: -2.92 mm to -3.08 mm), PAG (Bregma: -3.08 mm to -3.28 mm). (B) Statistical analysis of the number of c-Fos+ cells. The x-axis represents the control group and treatment groups, and the y-axis represents the count of c-Fos expressing neurons( ANOVA, PFC: F (2, 22) = 13.40, p = 0.0002, n: Ctl = 8,SS = 8, OS = 9; BLA: F (2, 21) = 8.544, p = 0.0019, n: Ctl = 8,SS = 8, OS = 8; PIL: F (2, 18) = 19.98, p < 0.0001, n: Ctl = 7,SS = 7, OS = 7; SUM: F (2, 18) = 17.87, p < 0.0001, n: Ctl = 7, SS = 7, OS = 7; CA2: F (2, 22) = 5.977, p = 0.0084, n: Ctl = 7,SS = 9, OS = 9; PAG: F (2, 20) = 10.68, p = 0.0007, n: Ctl = 7,SS = 8, OS = 8). Data are presented as means ± s.e.m. Statistical significance was determined using One-way ANOVA, Tukey’s multiple comparisons test, *p < 0.05, **p < 0.01, ***p < 0.001.
