Fig. 8 | Scientific Reports

Fig. 8

From: Efficacy of Naringenin against aging and degeneration of nucleus pulposus cells through IGFBP3 inhibition

Fig. 8

Effect of NAR on Igfbp3 protein expression and the senescence and degeneration phenotype of NPCs. (A) WB detected changes in the expression levels of Col2a1, Mmp13 Igfbp3, P21 and P16 after treatment of NPCs with NAR. (B) Changes in cell proliferation after NAR treatment of NPCs. Scare bar = 200 μm. (C) Changes in Aggrecan after NAR treatment of NPCs Scare bar = 50 μm. (D) Expression of SASP-related genes Il-6, Mmp3, Cxcl10 and Ccl2 after NAR treatment of NPCs detected by qRT-PCR.

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