Fig. 3

Liver histopathological changes in different groups. Representative hematoxylin and eosin (H&E) and Masson’s trichrome staining (MTC) photomicrographs of the hepatic tissue (400 × magnification). (A & a) CON; (B & b) Vehicle; (C & c) Dox; (D & d) Dox-C; (E & e) Dox-A; (F & f) Dox-AC; (G) the percentage of collagen deposition in different groups (n = 4/group). * P < 0.05 vs. the CON group; # P < 0.05 vs. the Dox group; $ P < 0.05 vs. the Dox-C group; & P < 0.05 vs. the Dox-A group. Abbreviations: CON, control group; Dox, doxorubicin group; Dox-C, doxorubicin + curcumin group; Dox-A, doxorubicin + aerobic interval training group; Dox-AC, doxorubicin + curcumin + aerobic interval training group.