Fig. 4 | Scientific Reports

Fig. 4

From: Mitigating doxorubicin-induced hepatotoxicity in male rats: The role of aerobic interval training and curcumin supplementation in reducing oxidative stress, endoplasmic reticulum stress and apoptosis

Fig. 4

Protein expression of endoplasmic reticulum stress markers in the hepatic tissue (A) representative western blot analysis of ER stress markers in the hepatic tissue; (B) p-IRE1ɑ/IRE1ɑ ratio; (C) ATF6/GAPDH; (D) p-JNK/JNK ratio; (E) p-PERK/PERK ratio; (F) GRP78/GAPDH; (G) ATF4/GAPDH; (H) p-eIF2ɑ/eIF2ɑ ratio; (I) CHOP/GAPDH. Data are presented as mean ± SD (n = 4/group). * P < 0.05 vs. the CON group; # P < 0.05 vs. the Dox group; $ P < 0.05 vs. the Dox-C group. Abbreviations: ATF4, activating transcription factor 4; ATF6, activating transcription factor 6; CHOP; C/EBP homologous protein; eIF2ɑ, eukaryotic initiation factor 2ɑ; GRP78, the 78-kDa glucose-regulated protein; IRE1ɑ, inositol-requiring transmembrane kinase/endoribonuclease 1α; JNK, c-Jun N-terminal Kinase; PERK, protein Kinase RNA-Like ER Kinase; CON, control group; Dox, doxorubicin group; Dox-C, doxorubicin + curcumin group; Dox-A, doxorubicin + aerobic interval training group; Dox-AC, doxorubicin + curcumin + aerobic interval training group.

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