Table 4 Serum levels of hepatic injury markers.

From: Mitigating doxorubicin-induced hepatotoxicity in male rats: The role of aerobic interval training and curcumin supplementation in reducing oxidative stress, endoplasmic reticulum stress and apoptosis

Parameters

CON

Vehicle

Dox

Dox-C

Dox-A

Dox-AC

SGOT (U/L)

64.12 ± 5.61

66.91 ± 6.56

165.2 ± 5.7*

117.3 ± 10.23*#

133.7 ± 4.89*#$

85.28 ± 5.95*#$&

SGPT (U/L)

68.88 ± 6.56

61.17 ± 5.89

136.2 ± 7.75*

113.8 ± 5.88*#

104.9 ± 9.48*#

82.32 ± 7.47#$&

ALP (U/L)

33.9 ± 8.38

32.89 ± 7.22

99.95 ± 11.68*

72.97 ± 11.1*#

85.33 ± 10.76*

66.05 ± 14.36*#

GGT (U/L)

1.4 ± 0.3

1.45 ± 0.22

4.41 ± 0.3*

3.19 ± 0.51*#

3.87 ± 0.2*

2.26 ± 0.23*#$&

T-bilirubin (mg/dl)

1.02 ± 0.14

1.02 ± 0.24

2.31 ± 0.28*

1.52 ± 0.18*#

1.75 ± 0.26*#

1.33 ± 0.2#

LDH (U/L)

4.47 ± 2.2

4.75 ± 2.34

45.03 ± 4.44*

40.92 ± 1.72*

26.89 ± 2.91*#$

17.21 ± 2.42*#$&

Albumin (g/L)

38.19 ± 3.08

36.38 ± 4.15

25.22 ± 3.98*

30.84 ± 2.97

25.65 ± 2.6*

34.43 ± 3.12#&

  1. The values are reported as mean ± standard deviation (n = 4/group). * P < 0.05 vs. the CON group; # P < 0.05 vs. the Dox group; $ P < 0.05 vs. the Dox-C group; & P < 0.05 vs. the Dox-A group.
  2. Abbreviations: ALP, alkaline phosphatase; GGT, gamma-glutamyl transferase; LDH, lactate dehydrogenase; SGOT, serum glutamic-oxaloacetic transaminase; SGPT, serum glutamate pyruvate transaminase; CON, control group; Dox, doxorubicin group; Dox-C, doxorubicin + curcumin group; Dox-A, doxorubicin + aerobic interval training group; Dox-AC, doxorubicin + curcumin + aerobic interval training group.
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