Table 5 The activity of oxidative stress-related markers in the hepatic tissue.

From: Mitigating doxorubicin-induced hepatotoxicity in male rats: The role of aerobic interval training and curcumin supplementation in reducing oxidative stress, endoplasmic reticulum stress and apoptosis

Parameters

CON

Vehicle

Dox

Dox-C

Dox-A

Dox-AC

MDA (µM/ml)

3.89 ± 1.24

3.69 ± 1.47

25.73 ± 1.27*

19.7 ± 1.3*#

17.91 ± 1.22*#

13.01 ± 2.11*#$&

SOD (IU/ml)

63.51 ± 3.16

65.1 ± 4.76

17.45 ± 5.49*

30.96 ± 6.62*#

46.63 ± 4.37*#$

51.73 ± 3.9*#$

CAT (nM/min/ml)

319.5 ± 14.99

309.8 ± 28.28

21.9 ± 12.94*

79.03 ± 15.61*#

217.8 ± 22.51*#$

262.5 ± 18.19*#$&

GSH (mg/l)

98.7 ± 7.46

94.48 ± 5.46

13.89 ± 5.94*

31.7 ± 6.67*#

42.37 ± 5.72*#

61.94 ± 11.32*#$&

  1. The values are reported as mean ± standard deviation (n = 4/group). * P < 0.05 vs. the CON group; # P < 0.05 vs. the Dox group; $ P < 0.05 vs. the Dox-C group; & P < 0.05 vs. the Dox-A group.
  2. Abbreviations: CAT, catalase; GSH, glutathione; MDA, malondialdehyde; SOD, superoxide dismutase; CON, control group; Dox, doxorubicin group; Dox-C, doxorubicin + curcumin group; Dox-A, doxorubicin + aerobic interval training group; Dox-AC, doxorubicin + curcumin + aerobic interval training group.
Back to article page